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KMID : 1200020160400040253
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Diabetes & Metabolism Journal
2016 Volume.40 No. 4 p.253 ~ p.271
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The Effect of Regular Exercise on Insulin Sensitivity in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
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Kimberley L. Way
Daniel A. Hackett
Michael K. Baker
Nathan A. Johnson
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Abstract
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The purpose of this study was to examine the effect of regular exercise training on insulin sensitivity in adults with type 2 diabetes mellitus (T2DM) using the pooled data available from randomised controlled trials. In addition, we sought to determine whether short-term periods of physical inactivity diminish the exercise-induced improvement in insulin sensitivity. Eligible trials included exercise interventions that involved ≥3 exercise sessions, and reported a dynamic measurement of insulin sensitivity. There was a significant pooled effect size (ES) for the effect of exercise on insulin sensitivity (ES, ?0.588; 95% confidence interval [CI], ?0.816 to ?0.359; P<0.001). Of the 14 studies included for meta-analyses, nine studies reported the time of data collection from the last exercise bout. There was a significant improvement in insulin sensitivity in favour of exercise versus control between 48 and 72 hours after exercise (ES, ?0.702; 95% CI, ?1.392 to ?0.012; P=0.046); and this persisted when insulin sensitivity was measured more than 72 hours after the last exercise session (ES, ?0.890; 95% CI, ?1.675 to ?0.105; P=0.026). Regular exercise has a significant benefit on insulin sensitivity in adults with T2DM and this may persist beyond 72 hours after the last exercise session.
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KEYWORD
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Aerobic training, Glucose tolerance test, Hyperinsulinaemic euglycaemic clamp, Insulin resistance, Resistance training
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